The Avian Influenza Virus Polymerase Brings ANP32A Home to Roost

Mehle A (2016). Cell Host Microbe 19(2):137-8.
PubMed Record

Avian influenza virus polymerases function poorly in mammals, restricting transmission across species and the emergence of pandemic outbreaks. Long et al. (2016) have now identified ANP32A as a crucial cellular protein that dictates species-specific polymerase activity.

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The Barclay lab has implicated ANP32A as a host-specific enhancer of viral polymerase activity